Part II of the paper reports the experimental validation of the LSSE LSPP model and a study of the sensitivity of the model with variations in the model parameters.
In this approach, sets of many simulations of the same model with variations in parameters representative of cell-to-cell variability sources (the sources of this variability are discussed in the next section) are used to approximate the behavior of an ensemble of cells.
A polygenic model with variations in several loci, each contributing a modest independent risk has been shown to best explain the residual non BRCA1/2 aggregation of breast cancer, and the effect of low penetrant genes may also at least partly explain sporadic breast cancer [ 2, 3].
MSM, MSMH, MSI, MSIH, MSIA, and MSIAH implies a Markov switching model with variation in mean, mean and variance, intercept, intercept and variance, intercept and autoregressive parameters, and intercept, parameters, and variance, respectively ***, **, *Denotes significance at the 1, 5, and 10%, respectively.
Moreover, this function provides a robust fit across a range of epidemiological scenarios, as shown in Figures 1a,b and c for, respectively, the SIR model with variation in susceptibility and infectivity, with additional variation in recovery rate, and the SLIRS model.
The 4 models (with variations) considered are nonlinear and have different forms of neural-fuzzy structure.
In situations where all possible households are to be covered, it is advisable to run the models with variations of p until the constraint (mathop sum nolimits_{j} Y_{ij} = 1) holds.
The modified model deals with variations in DES molar composition and temperature in a more consistent way than the original Rackett model which exhibits monotonic performance degradation as temperature moves away from reference conditions.
The investigation is performed on synthetic models with variation of q in the interval from 30 to 0.001.
Model simplification was based on an analysis of the factors affecting survival and resighting probabilities and constructed models with variation between age and time, and the age*time interaction.
Simulation of the models with variation of their sequestration strength revealed that feedback loop from Phos2 to MKKK-P could be abolished in both M4K1 and M4K2 by increasing the phosphatase sequestration strengths.
