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The kinetic and thermodynamic studies revealed that the biosorption process was well suited with pseudo-second order kinetic model with spontaneous and endothermic in nature.
Akita mouse, a diabetic model with spontaneous mutation of insulin 2 gene [30], was used to test whether the abnormalities in cumulus cells were caused by streptozotocin itself rather than maternal diabetes.
Only one animal model with spontaneous autoimmune peripheral polyneuropathy has been reported in non-obese-diabetic (NOD) mice [ 5].
This is the first study to examine the factors that lead to RN in a mouse model with spontaneous VUR.
The controlled release of CXB from this hydrogel resulted in limited inhibition of PGE2 production in a large animal model with spontaneous IVD degeneration.
Dogs constitute a potentially more relevant clinical model with spontaneous neoplasms occurring in an outbred immuno-competent large mammal compared to the traditional experimental animal setting [ 13].
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As identified by Morrison et al. [ 33], the advantage of such a model compared with spontaneous models of chronic ocular hypertension is that the timing of the IOP increase following the surgical intervention is known.
Few experiments using animal models, with spontaneous tumors, have been performed.
Further researches are anticipated by using animal models with spontaneous hemorrhagic AVM lesions.
Much of what we know regarding the role of desaturases in the skin comes from studies using mouse models with spontaneous or targeted deletions of specific desaturases, especially delta-9 desaturases.
Owing to the lack of brain-dominant lesions, Milton et al. successfully generated mouse models with spontaneous AVMs in the brain and/or spinal cord by deleting Alk1 in the embryo by SM22-Cre, which was expressed in smooth muscle cells, ECs, and some other cell types in different organs [ 32].
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