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The reduced model, with prognostic indicators included whose inclusion frequency exceeds a threshold of 90% showed apparent c-indices between 0.72 and 0.74.
The only model with prognostic significance was a 2-cluster one, with a borderline association to favorable OS (p=0.048) and earlier TNM stage (p=0.027 for stage IIB-III vs. IV).
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For this method the intercept and regression coefficient of the logistic regression model with the prognostic index as the only predictor (recalibration model) are used to transform the prognostic index and compute recalibrated probabilities from this recalibrated prognostic index.
A 19-gene model with optimal prognostic performance in the training set discriminated between a high and a low-risk group for OS in the two validation sets, while maintaining its independent association with survival in multivariate analysis adjusting for known clinicopathologic confounding factors.
Including it into a model with established prognostic factors will increase the accuracy of prognosis.
This particular approach consists of fitting a Cox model with the prognostic score as the only predictor.
For each of the new factors, a multiple Cox model with known prognostic factors as adjustment variables was calculated.
Discrimination C-indexes and Nagelkerke's R coefficients were computed for the model with clinical prognostic factors only and for various models with added HRQOL scores.
The AIC was analysed using Cox proportional hazards regression model with other prognostic covariates, including age (continuous), gender, histological type, chemotherapy type and radiation technique.
Elevated neutrophil counts, elevated platelet counts, and a high neutrophil lymphocyte ratio were significant independent predictors for shorter OS in a model with established prognostic factors.
A logistic regression model with potential prognostic factors (disease stage, histology, sex, age, performance status, weight loss, and liver metastases) showed that the presence of liver metastases was a significant independent negative prognostic factor for tumour response.
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