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A two-level model with grouping of patients within centers would include residuals at the patient and center levels.
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Model-based (grouped) uses a flexible parametric model with grouped age and applying Eq. (2).
We used a Bayesian, hierarchical, community occupancy model with group-specific hyper-parameters to estimate occupancy probabilities and species richness while accounting for imperfect detection.
An ANCOVA with a general linear model, with group and follow-up time point as fixed factors, was used to compare the average NRS scores at each follow-up period between the two groups.
For secondary outcomes we will use a mixed model with group as a fixed factor.
A mixed model with group as a fixed factor will be used for the other outcome measures.
The change in perceived pain (0 10 scale) will be evaluated using a repeated measures linear mixed model with group, time and group by time interaction as independent variables.
To look for a difference in the mean statistics between groups, we used a linear model with group as the dependent variable.
When analysing the D-probe phenotype, we used a five-group model with groups for MZ male, MZ female, DZ male, DZ female and DZ opposite-gender pairs.
The effect of clinical diagnosis on blood and serum components was analysed with a general linear regression model, with group of clinical diagnosis as the only explanatory variable.
Statistical analysis was conducted on log transformed AUC0-∞ and Cmax using an analysis of variance model with group as a fixed factor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com