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Consider a regression model with exposure X and true confounder Z, that is, Instead of the true confounder Z, we observe an error-prone proxy variable V.
33 34 We estimated the propensity score using a logistic regression model with exposure to a specialist team as the independent variable.
4, 16 Clinical trial testing of this model, with exposure to infected mosquito bites replaced by PfSPZ Challenge, is in progress.
We also ran a model with exposure to cat allergen as a covariate and stratified the model according to measured exposure to cat allergens.
The fit of this model with exposure time windows defined jointly by age at exposure and time since exposure was substantially better than the fit of a model for lifetime cumulative exposure (LRT = 16.9, 5 df, p-value = 0.005).
These statistics suggest that the model with exposure to heavy motor vehicle traffic explained 22.6% of the variance of asthma diagnosis in this population while the model with language explained 24.7%.
Similar(53)
Tan et al. (2006) incorporated variability into the reverse dosimetry of chloroform using a combined physiologically based pharmacokinetic (PBPK) and shower exposure model, with external exposure calculated using an exposure conversion factor (ECF) distribution.
Chi-square tests for trend were used for all exposure response models with exposure levels assigned 0, 1, and 2 for nonexposed, ≤ the median, and > the median.
Addition of each of the thyroid hormones (TSH, T3, total T4, free T4 or T3-uptake) separately to models with exposure group, age, BMI group, and lipids did not change the exposure relationships with diabetes (not shown).
To evaluate possible departure from linearity, likelihood ratio tests were used to compare the fit of models with exposure quintile as a categorical variable versus quintile as a linear term.
Associations that were significant at the p < 0.05 level in models with exposure represented as a continuous (log-transformed) variable we further examined by substituting tertiles of the biomarkers (micrograms per gram creatinine) to assess the linearity of the effects.
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