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NRI evaluates the net number of individuals reclassified correctly as high versus low risk for diabetes using the model with elevated HbA1c compared with the model without elevated HbA1c.
Our laboratory recently developed an animal model with elevated endogenous GH levels associated with a small (25%), but significant, increase in IGF-I (HiGH mice).
Considering the initial promising in vivo data in an LPS rat model with elevated P2X7 expression, this work constitutes an important step in the development of a radiotracer useful for the diagnosis and monitoring of clinical disorders with associated neuroinflammatory processes.
Goto-Kakizaki (GK) rats are a polygenic model with elevated blood glucose, peripheral insulin resistance, a non-obese phenotype, and exhibit many degenerative changes observed in human T2DM.
Furthermore, CR (2 mo; 70% of AL) increased MDA by 3-fold in the liver and by 50% in the heart of male Sprague-Dawley rats, an animal model with elevated basal levels of stress-induced corticosterone, vs. AL-fed rats [39].
Our current data confirmed this TNBS-induced colitis model with elevated Th1-like cytokines.
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We have in a previous study shown that lack of HRG affects the angiogenic switch in the RIP1-Tag2 model with significantly elevated numbers of angiogenic islets in RT2/HRG−/− mice as compared with RT2/HRG+/+ littermates at 7 weeks of age [3].
AMD473 also showed a lower increase in IC50 than cisplatin in an A2780 cell line model with artificially elevated glutathione levels.
Similarly, prostate-specific loss of PTEN in a murine model resulted in tumors with elevated AKT and mTORC1 activity.
However, recent studies in genetically altered mouse models have largely solidified the calcium hypothesis of MD, such that models with artificially elevated calcium in skeletal muscle manifest fulminant dystrophic-like disease, whereas models with enhanced calcium clearance or inhibited calcium influx are resistant to myofiber death and MD.
As important markers to evaluate liver function, the serum levels of AST and ALT in CCl4-induced model group substantially elevated compared with blank control group, while DWYG treatment significantly inhibited the increase in serum levels of ALT and AST induced by CCl4.
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