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Furthermore, in a departure from the pig model, the authors have started to develop the goat as a repeatable surgical model with easy access into the joint space in skeletally mature animals.
The chapter briefly describes the general steps to solve the nonlinear control problems: First, find a linear system model of the nonlinear system; second, design the controller assuming the system to be linear; third, embellish the linear model with easy and accurate features; and fourth, embellish the controller design with features to keep the system designs within parameters.
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The common failures to translate promising preclinical drug candidates into clinical success and the endeavors to realize precision medicine highlight the urgent call for a model system with easy accessibility, high physiological relevance and ability to incorporate patient-specific disease background.
Moreover, the possibility of applying chemo-radiotherapy to this model together with easy surgical removal of tumour masses offers new perspectives to test current available patient therapy in a pre-clinical model.
Our method is tested against and outperforms the most common approach in literature, genetic algorithms, and shows its important real-world applicability to problems that combine black-box models with easy-to-quantify objectives like cost.
This paper describes the development of a simulation model with an easy-to-use graphical user interface for the biofuel supply chain.
The framework provides users with easy access to the internal structures of complex environmental models.
The above loglinear model with interaction terms is easy to fit in standard statistical software such as SAS (example code is provided in Additional file 1).
With the well-defined morphology and chemical structure, combined with easy preparation, these model surfaces provide excellent means to explore the molecular level phenomena, taking place during various processes involving cellulose.
The purpose of this study was to develop a PTT-based blood pressure estimation method with personalized model and easy implementation.
This model is easy to calibrate with only a few required parameters that are provided by car manufacturers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com