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We estimate the model with country and year fixed effects and allow for standard errors that are clustered across countries.
We also estimated a pooled model with country interactions to formally test for heterogeneity of associations by country.
Within-subject variation of self-monitored plasma glucose was estimated using a variance-component model with country, treatment and age as fixed factors and subject as random effect.
Analysis of changes in SIB domain scores at week 24 was performed using an analysis of covariance model with country, treatment, and baseline as interaction terms.
In addition to the random-effects models, we estimated an overall multivariate model with country fixed effects and found the following variables to be positively associated with depressive symptoms: chronic disease, lower SES, female, and living in a non-multigenerational household (Additional file 1: Table S2).
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We use a linear model with country-level random intercepts based on a panel of 24 cobserved14 observed in 2002 2012.
The funding model, with countries' contributing proportional to their annual revenue, could replicate the way other joint military ventures operate. .
Since our data structure is best described as hierarchical (parties nested in countries), we run a multilevel model with country-level random intercepts.
Mixed generalised linear models, with country as a random effect and stratum (age*sex) as a fixed effect, will be used to estimate prevalence and incidence.
In addition, likelihood ratio tests were performed comparing the multilevel models to conventional linear regression models (with country dummies), and these tests revealed better model fits in all cases.
A sequential series of models with country and age (younger than 50 years versus 50 years or older) as a starting point and then adding ER, grade, and the ER/grade combination to test for interaction between ER and grade.
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