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This study is designed to investigate the effect of 1,25(on)2D3 on ethanol-induced intestinal barrier dysfunction and the underlying mechanisms utilizing Caco-2 cell monolayers and a mouse model with acute ethanol injury.
This IIDS was tested in an ambulatory porcine model, with acute coronary occlusion precipitated by stent thrombosis.
Vagotomy blocked the effect of ICV NPY on gastric acid secretion in a urethane-anesthetized rat model with acute gastric fistula.
To evaluate this hypothesis, a rat model with acute myocardial infarction was used, and the therapeutic hydrogels were injected intramyocardially in the peri-infarct regions.
We have demonstrated for the first time in the literature that acute hyperglycemia with no preceding diabetes mellitus abolished the infarct size limiting effect of RIPerC in an in vivo rat model with acute coronary occlusion and reperfusion.
The ultrastructural changes in AECIIs after high-frequency oscillatory ventilation (HFOV) with a high lung volume strategy or conventional ventilation were evaluated in a newborn piglet model with acute lung injury (ALI).
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In brief, modeling with acute traumatic brain injury models in the midbrain or sensory-motor cortex, RADA16-I SAPs nanofiber scaffold was found to bridge the injury gap, to reconstruct the lesion cavity, and/or to promote knitting of the wounded tissues.
Recently, more viable GCase mouse models with acute neuronopathic Gaucher disease have been generated (19, 20).
The fact that protein expression of the collagenases MMP-1 and MMP-13 was accompanied by elevated TIMP-1 levels is compatible with results in chronic pressure- overload induced hypertrophy but contrasts to models with acute pressure-overload showing an increase in MMP activity [ 22]. β1TG mice developed dilatation and heart failure at the age of 12 months [ 11].
We successfully managed to establish a model with unilateral acute kidney injury seen as low urine production and GFR as well as increased apoptosis quantified with detection of caspase-3-active cell profiles in the kidneys subjected to ischemia.
Employing a mouse model with inducible, acute β-cell ablation, we uncovered an essential role of adiponectin under insulinopenic conditions to maintain minimal lipid homeostasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com