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"The earlier arriving species almost always win in the competition in our model, which recapitulates what we've observed in Jasper Ridge," Uricchio said.
For our in vitro studies, we used culture-activated HSCs seeded on fibronectin-coated glass, a widely employed model, which recapitulates the activated phenotype in vivo with good approximation.
Therefore, we chose the well described HSE tissue model, which recapitulates human skin and wound healing, to test antibodies directed at β4.
We investigated the role of Rest in neural development using an in-vitro ES cell-derived neural differentiation model, which recapitulates events during neural development in vivo.
Good animal models for HIV and TB exist, but there is not a model which recapitulates HIV-infection in an individual with latent TB.
In summary, these results indicate that the layered rLSEC-PEM-hepatocyte model, which recapitulates key features of hepatic sinusoids, is a potentially powerful medium for obtaining comprehensive knowledge on liver metabolism, detoxification and signaling pathways in vitro.
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This can only be achieved through the use of functional models which recapitulate all aspects of the human disease.
Here, by considering minimalist mathematical models, which recapitulate scaffold effects seen in more mechanistically detailed models, we obtain analytical and numerical results that provide insights into scaffold function.
Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process including the effect of the ageing process.
A number of murine MB models have been created allowing comparative analyses (reviewed in [ 16]), including models which recapitulate WNT [ 4] and Group 3 [ 17, 18] tumours.
In addition, a high-fat diet inducing inflammation in K-Ras (G12D) mouse models, which recapitulate human PDAC, was shown to enhance tumor promotion.
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