The remaining simulations used regional air quality models, which necessitates downscaling global climate model data to fine scales (e.g., 36-km grids).
This is especially important because building an integrative view of mitochondrial networks will require multi-scale computational modeling, which necessitates quantitative experimental data for comparing model to experiment and testing model predictions.
However, FD platforms are limited in their application in small animal imaging due to the small volumes encountered in murine models which necessitates the modulation of the source in the GHz range for robust contrast in the phase function [ 12].
Furthermore, the industry is slowly transitioning towards sophisticated Building Information Modelling (BIM), which necessitates the integration of domain specific knowledge into the BIM authoring tools.
Also, we did not include failure of first-line cART in our model, which would necessitate progression to second-line cART.
The primary focus here is the application of the methodology to a complex model whose computational expense limits the number of model evaluations to an extent which necessitates the use of surrogate models.
The KPC model has a variable latency, which necessitates the use of manual palpation and non-invasive imaging modalities, both to identify animals that carry tumours and to determine tumour size.
While many of the models consider idealized geometries and are able to provide insights into the underlying mechanisms, it is essential to place such models in an anatomically realistic setting, which necessitates an interdisciplinary approach combining the fields of mathematical modeling, scientific computation, and medical imaging.
Our objective is to model the heterogeneous response of cell populations in order to estimate histological effects due to different treatments, which necessitates a modeling paradigm with individual cell clarity.
