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It has been recently reported in an animal model, where mice with subcutaneous implantation of Lewis Lung Carcinoma were subjected to an operative injury, that surgery induced the release of cytokines/chemokines and mobilized bone marrow-derived cells[59].
In the present study we tested the anticancer potentials of ethanolic extract of roots of P. senega (generally used as a homeopathic drug) in a mammalian model, where mice, in vivo, were treated chronically with benzo[a] pyrene and in vitro where lung adenocarcinoma cell line (A549) were used.
Pivotal studies are presented in more detail to demonstrate the use of the new methods: the in vivo investigation of bacterial virulence factors and host interaction in a human colonization protocol; the experimental mouse UTI model where mice strains differing in genetics demonstrate selective dysfunctions; the search for human polymorphism explaining suceptibility to infectious diseases.
Our base model was a 2-level model where mice were nested in strains with sex and clade membership included as covariates.
Herein, we describe an oncogene induced mouse mammary tumor model where mice lacking jnk2 experience higher tumor multiplicity and genomic instability.
Thus, to study obesity and diabetes, we employed the diet-induced mouse model where mice were fed on a "high calorie diet" consisting of high-fat and high-sucrose (HFHSD).
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Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention.
Alveolar hyperplasias are frequently observed in models where mouse mammary tumor virus, hormones or chemical carcinogens are the initiating agents.
This study was the first to investigate the impact of exogenous cannabinoid administration in an acutely stressed mouse model, where CD1 mice were pre-treated with HU-210, a potent CB1R agonist, prior to acute stress exposure and subsequent behavioral testing.
Cognition tests and memory assessment were done based on a water maze model where the mice had to find their way to a platform using given cues.
For this purpose, we used an experimental model where C57BL/6 mice were challenged with different doses of parasite of the Y strain of Trypanosoma cruzi.
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