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The parameters of the model were either directly extracted from observation (e.g. observed initiation rate, percentage of emergence, number of simultaneously developing primordia), or estimated through extensive parameter space exploration and comparison between model outputs and observation (see Supplementary Figure S3 for a detailed outlook of the reference used for parameters calibration).
The variables selected for the multivariate model were either significant (p-value <0.05) in the bivariate analysis or shown to be significant in previously published studies.
Independent variables considered in the regression model were either significant factors from the univariate analysis or plausible confounders from previous studies in Nepal [ 11, 15, 16].
The variables selected for the multivariate model were either significant (p-value < 0.05) in the bivariate analysis or shown to be significant in previously published studies [ 16- 18].
Due to the limited availability of experimental data from the mouse SAN for some ionic channel currents, some parameters in the model were either based on parent models (36, 37, 89) or estimated to reproduce ion channel I-V relationships, experimentally observed mouse SAN AP features, and the functional role of individual modeling components.
First-line treatments in the model were either 2 days of inpatient and 10 days of outpatient intravenous vancomycin 1 g every 12 hours, or 2 days of inpatient intravenous linezolid 600 mg every 12 hours followed by 10 days of outpatient oral linezolid 600 mg every 12 hours, or 2 days of inpatient and 10 days outpatient intravenous daptomycin 4 mg/kg (300 mg for 75 kg patient) every 24 hours.
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I agree with the World Bank report which noted in 2009 that "there is little evidence that the large-scale farming model is either necessary or even particularly promising for Africa".
For b > 0.02 the model is either equilibrium (quiescence) or exhibits tonic periodic oscillations.
However, for all of the cities the best model was either from categories (1) or (2).
Also, the values of the parameters used in our model are either drawn from freely available literature or determined.
The calibration methods based on this conventional model are either complicated to operate or deriving non-identical system parameters.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com