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To further characterize our model, we profiled a panel of therapeutic agents such as, etanercept, dexamethasone and buprenorphine.
To understand the underlying molecular mechanism of the deficit in apoptotic cell clearance observed in our mouse model, we profiled the transcription of a set of genes encoding phagocytosis-associated receptors and opsonins in PPARγ-WT and PPARγ-KO macrophages.
To examine the role of the post-transcriptional regulators of adipogenesis in a physiologically relevant model, we profiled primary white and brown pre-adipocytes before and after differentiation into mature adipocytes (n = 3+3 for each tissue type) using Exiqon miRNA arrays, v.8.1.
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Using the estimated model, we generated utility profiles as a function of distance and various other attributes, allowing us to represent visually the trade-offs that individuals make in the decision process.
To build our model, we compared HI profiles in six nutrient environments against 23 systems-level gene properties.
Using genomic imprinting as a model we examine epigenetic profiles associated with different forms of gene regulation.
However, this pattern is less obvious for the profile B. Using a mathematical model, we identified six typical profiles of geographical and temporal spread of an influenza pandemic, and the two key parameters influencing these profiles: the proportion of susceptible individuals in the initial population and the basic rate of transmission between individuals.
Like any business model, we have successful high-profile owners who don't want to be throwing their money out the window".
Thus, to study the interplay of transcription and chromatin in the HCC1806 preclinical model, we performed nascent transcription profiling using Precision Run-On coupled to sequencing (PRO-seq).
Using this model we show that metabolic profiles solely measured in venous blood are not sufficient to uniquely parameterize the model.
To question the correlation between PARK2 and adiposity in another animal model, we compared its expression profile between the two same mice models used for JAG2 study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com