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With respect to this architecture, the VSN business model we envisage foresees an open market environment, which enables open competition and flexible service provisioning.
Indeed, in our model, we envisage that certain cellular interactions or post-translational modifications, such as phosphorylation [10] or SUMOylation [12], may temporally and spatially regulate NS1 conformations.
In this model we envisage that a region of Snf1 between the kinase domain and the ordered C-terminal domain, which is not conserved in AMPKα, plays a role analogous to the α-hook in AMPK.
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Given the increasing number of sequenced genomes and corresponding stoichiometric models, we envisage that the proposed strategy could be extended to address a growing range of biological questions and engineering applications.
For Argos, for example, we envisaged a circular business model built on the strapline Lease it.
To support Model A further, we envisage a novel mechanism of how FLA proteins might influence ABA signalling.
We identify desirable features for models, and describe some of the potential advances that we envisage for model components and their integration.
In the projects that we envisage, modeling is not the final goal; rather, it is a tool that can be used to advance understanding of the system, to develop more directed experiments in the laboratory and, ultimately, to generate testable predictions to enable improved therapies and prophylaxes.
Although our model is generic and so does not depend on a choice of a particular time step, we envisage our model to apply to relatively fast-spreading epidemics.
We envisage a model where TFE engages with and possibly opens the RNAP clamp, which stimulates open complex formation and transcription.
We envisage a model for community-driven knowledge bases where the original portal development is funded through a classical grant, but where the curation of the knowledge base is gradually shifted from the core development team to the community at large over the period of the grant (3 to 5 years).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com