Sentence examples for model we engineered from inspiring English sources

Guided by a genome scale metabolic model, we engineered the E. coli host metabolism to enhance anaerobic production of succinic acid by deleting the gnd gene, considering its location in the boundary of oxidative and non-oxidative pentose phosphate pathway.

Using HLA-A2.1.1 restricted epitopes from the Melan A/MART-1 or gp 100 melanoma-associated antigens as a model, we engineered a series of constructs in the ALVAC canarypox vector system: T cell epitopes were expressed either as linear polyepitopes (with or without spacers), or as minigenes encoding a single epitope.

To extend these observations to a human breast cancer model, we engineered two cell lines overexpressing GPNMB/OA.

To specifically assess the role of endogenous Bcl-x in regulating apoptosis and tumor progression in this model, we engineered a pancreatic β-cell-specific knockout of both alleles of Bcl-x using the Cre-LoxP system of homologous recombination.

To test this model, we engineered a myosin V/VI chimera containing the myosin V motor domain with the flexible myosin VI lever arm and a myosin VI/V chimera consisting of the myosin VI motor domain with a rigid myosin V lever arm.

As a model system, we engineered cardiomyocyte- (I-1) and endothelial-targeted (B-40) liposomes to carry a VEGFR2 inhibitor (PTK787), and examined the effect of cell type-specific delivery on both pharmacokinetics (PK) and PD.

To understand how the complex network of DC lineages is generated in a model system, we engineered an Id2-GFP mouse reporter strain that enabled us to track endogenous Id2 expression on a single cell level during DC differentiation.

In order to facilitate mouse model studies, we engineered a murine Ews/Fli-1 fusion gene to mimic the human fusion gene formed by the most common chromosomal translocation, t(11 22)(q24;q12), observed in ES/PNET.

Additionally, aiming at creating the first mammalian HBSL model, we genetically engineered and phenotyped mutant mice with a targeted Dars locus.

To further improve our humanized niche scaffold model, we genetically engineered human MSCs to secrete human interleukin-3 (IL-3) and thrombopoietin (TPO).

To clarify the roles of TNF-α against HIV-1-related virus infection in an SHIV-macaque model, we genetically engineered an SHIV to express the TNF-α gene (SHIV-TNF) and characterized the virus's properties in vivo.