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Using a Nf1 heterozygous mouse model, we discovered a striking phenotype whereby OPCs formed discrete, hyperdense foci.
"Using our computer model we discovered that the habitable zone for an Earth-like planet orbiting a sun-like star is about three times bigger if we include the top five kilometres below the planet surface.
Using our new animal model, we discovered that postnatal cardiac ablation of Sirt5 resulted in persistent accumulation of protein succinylation up to 30 weeks after SIRT5 depletion.
Using this zebrafish screening model, we discovered two independent suppressors (sunshine and eos) [ 2].
In agreement with the model, we discovered a positive correlation between LC3 level and AV size across single cells.
By using the Rasch model, we discovered that specific items should be discarded and other items should be reformulated to make the questionnaire more "on target".
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Using an embryonic stem cell (ESC) model, we discover two successive functions of FGF/MAPK signaling in this decision.
By combining experiments with mathematical modeling, we discovered a reciprocal dose and duration response relying on the orchestrated action of three kinases (AtWNK1, AtWNK8, and AtWNK10) acting on distinct timescales and activation thresholds.
By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of >20 in vitro and in vivo resistance models, we discovered that major pathways of resistance converge to activate the transcription factor, c-MYC (MYC).
By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of >20 in vitro and in vivo resistance models, we discovered that major pathways of resistance converge to activate the transcription factor, c-MYC (MYC).
Of special note, nine of the unannotated mouse models we discovered (discussed earlier) encode predicted proteins with fingerprint patterns that match annotated genes in human and other species extremely well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com