In the allergic asthma model we administered VSL 3, a commercial combination of probiotic bacteria (bifidobacterium, lactobacillium and streptococcus), orally for 6 weeks before the first i.p.
To determine if the results from epidemiologic studies could be repeated in an animal model, we administered PM 2.5) from Hettstedt and Zerbst to ovalbumin-allergic mice.
To confirm this mechanism in our model, we administered LPS by i.p. injection to Vil-Cre Myd88 −/− mice that specifically lacked intestinal TLR signal transduction (Fig. 3E).
To extend results from in vitro experiments to an in vivo model, we administered PCB-77 to WT or AhR-deficient mice or to hyper-cholesterolemic ApoE−/− mice.
To examine the antibody response to the recombinant protein in an animal model, we administered the endotoxin-free fusion protein rGP5-FljB via an intraperitoneal injection.
To establish the diabetes model, we administered an intraperitoneal injection of STZ stock solution at a dose of 55 mg/kg for the model group (n = 50), completing the injection within 10 min.
In order to examine the role of endogenous activin A in this model, we administered recombinant human follistatin into the UUO-operated rats and assessed the effects of activin blockade on histological changes of the kidneys after UUO.
To determine the effect of CA4P treatment on the distribution of In labelled EOCs in a tumour model, we administered In labelled human EOCs into the tail vein of 3 different mouse strains and investigated the tracer distribution 24 hours after 25 mg/kg CA4P and EOC administration.
To test this hypothesis in our zebrafish model, we administered AVT at three doses intraperitoneally (i.p). to dominant males and observed a highly significant reduction in their aggression (to 7-307-30%sham; paired t-tests: t6 = 4.568 and P = 0.004; t7 = 5.227 and P = 0.001; t8 = 7.286 and P < 0.001; for 0.5, 1, and 5 μg/g.b.w. doses, respectively; Fig. 4A).
To determine if PPC could affect the Th1/Th2 balance in a very different immunologic model, we administered aged B6C3F1 mice 23-255 moldh old males) with relatively low levels of PPC (5 or 50 μg/mL) in their drinking water ad libitum for 25 days.
