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The model was valuable in prospectively predicting human PK for four investigational drugs tested to be OATP substrates in vitro.
The overall findings from this literature analysis are in complete agreement with a recent cross-company data-sharing initiative, which demonstrated that the conscious dog telemetry model was valuable for predicting QT outcomes in a phase 1 clinical study (Ewart et al., 2014; n = 113 small molecules in dataset).
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It is concluded that the proposed model is valuable and could be embedded into a multiscale modeling framework to deal with concurrent nucleation, growth, coarsening and macroscopic transportation.
The model is valuable in confirming or elucidating the various mechanisms in the polymerization.
The information awarded by the model is valuable for the design of targeted swelling hydrogel drug delivery systems.
Such a model is valuable because it quantifies the effects of extension alternatives and finds extremely good solutions for this large combinatorial problem.
The model is valuable for assessing the consequences of underwater hydrocarbon releases, providing input for subsequent modeling of gas dispersion or liquid pools and pool fires.
It is concluded that the proposed model is valuable in identifying alloy composition and processing parameters to optimize as-cast grain size.
The plastic equivalent model is valuable and essential for the further research on the press bend forming process of large scale complicated integral panels.
In addition, atomic structure parameter, deduced from atomic cluster model is valuable in the design of Mg Ni La Co system alloys with good glass-forming ability.
We believe that the presented animal model is valuable and well suited for further investigations on organ-specific consequences of systemic hemolysis and concomitant hyperoxemia in an immature physiology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com