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The kinetic model was manually constructed without external libraries.
The model was manually rebuilt using XtalView (McRee 1999).
The model was manually calibrated to upper Marx Creek stream discharge and site groundwater levels.
The Marx Creek model was manually calibrated to hydraulic head values observed in the monitor wells and stream discharge values collected from upper Marx Creek.
A model was manually built into the modified experimental electron density using COOT (Emsley and Cowtan, 2004) and further refined in PHENIX.
The initial model was manually rebuilt using COOT [44].
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In addition, the Information Delivery Manual (IDM) that includes exchange specifications needed for each exchange process of a product model is manually defined in a paper-based document.
If an error is detected, the program or the model is manually modified and verified again.
For instance, in [28] the floating-point model is manually converted into a hybrid code model by defining fixed-point word widths at some "important" locations; the remaining floating-point values are then interpolated by analytical means.
The remaining parts of the model were manually built using the program O and refined with the program CNS [17], [30].
The reactions and genes in the draft model were manually reviewed using the gene annotations and the available biochemical and physiological information.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com