However, the identification of currently unknown metabolic factors using mammalian model organisms is inefficient and expensive compared with studies using fish models such as zebrafish (Danio rerio) and medaka (Oryzias latipes).
MHC genotype has been linked to survival in several studies, which measured survival directly [ 42] or identified protective alleles against fatal forms of disease using fish model systems [ 43- 45].
Another key feature is the potential to perform high-throughput drug screens of chemical libraries using fish models of disease.
28 Whilst in this study we focused on the role of cumulative UVA exposure on skin aging, in recent years there has been increasing interest in its ability to promote carcinogenesis following published research using fish models of sunlight-induced malignant melanomas.
These efforts not only further the goal of using fish disease models for translation to the clinic, but also provide proof-of-principle that synthetic lethal screens will be fruitful in the zebrafish system.
Dr. Binoy explores the biological and environmental basis of decision-making and personality traits (also referred to as individual variation in the behaviour or behavioural syndrome) in vertebrates using fish and amphibian model systems.
Pioneering experiments demonstrated that fish can completely regenerate the heart following resection of the heart apex [ 9], a finding that has spurned multiple studies using fish as a model organism [ 10- 14].
A fish behaviour model using a psycho-hydraulic wheel activated by the stimuli of the fishing gear is established.
He had been interested in problems of endocrinology and had started using fish as genetic models ("Rats are just terrible to work with," he said, a New Yorker's reaction), and then he had become as interested in the problems presented by raising fish as in doing the experiments the fish were being raised for.
The marine medaka Oryzias melastigma (O. melastigma) is an emerging marine fish model used in the investigation of the response of organisms to pollutants, toxins and stresses in marine environments [ 5, 6].
