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Contrary to the classical continuum model, the inertia gradient nonlinear continuum model used herein is able to capture scale effects, which arise for modes in which the wavelength is comparable to the characteristic distance of the structured solid.
It is worth noting that with the model used herein, the coefficients are vanishingly small.
However, as emphysema model used herein was associated with pulmonary hypertension, high levels of PEEP should be avoided, as they can compress alveolar capillaries and elevate pulmonary vascular resistance regardless of ventilation mode.
We wish to emphasize, however, that the model used herein describes general characteristics of stretch-induced stress fiber dynamics and does not attempt to describe finer details of cytoskeletal remodeling or intracellular signaling.
In the model used herein, N-hTERT keratinocytes expressing telomerase and lacking functional p16INK-4a wexposedoseightghtimeses to UVB at a dose of 300 mJ/cm2 per exposure as described in the materials and methods.
Consistent with previous findings in the gut and brain of genetically obese mice, the dietary obesity model used herein exacerbated leukocyte and platelet adhesion in terminal hepatic venules.
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The fibrotic models used herein were the very popular bleomycin-induced skin and pulmonary fibrosis in mice.
37 The models used herein were constructed from the crystal structure of Ls-AChBP (PDB-ID 1I9B) following a procedure similar to that reported in Ref. 40 and building on our own previous work.
The tumors in the three mouse models used herein either expressed minimal ERBB2 (CHO-K1) or overexpressed it (CHO-K1/ERBB2 and BT-474), and either grew subcutaneously (CHO-K1 and CHO-K1/ERBB2) or orthotopically in the mammary fat pad (BT-474).
Thus, the in vivo efficacy of the mannosylated ECD/Her2 in the models used herein suggests that in addition to the antibody recognized epitopes, HLA.A2.1-restricted epitopes exist on this domain which are immunogenic enough to induce efficient antitumor CTL responses in vivo.
In the model setup used herein, the dynamics is driven by restoration to a prescribed temperature field.
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