38, 39 Likewise, Nguyen et al. analyzed the viral kinetics during treatments with alisporivir and/or peg-IFN 40 and found that using the PK-VK model improved the fitting criterion (BIC) and reduced the residual errors by nearly 20%, compared to the CE model (unpublished result).
We also obtained the same tree, with similar clade credibility values, from less favored, more complex models (unpublished results).
Kaufmann and Meiler find that R osettaL igand successfully docks a variety of small molecules into comparative models (unpublished results).
We also performed tests using separately the somatic, axonal and dendritic subsets of features on some of the selected models (unpublished results).
This drug also inhibits metastasis of oral squamous cell carcinoma to the cervical lymph nodes in an orthotopic mouse model (Agostini M, unpublished results).
In this publication, the variables and questions associated with the development of in vivo models are examined and several unpublished results are presented.
Our ongoing behavioral screen has identified mutants of several different targets that exhibit altered locomotor or eclosion rhythms (Y.H., M.A.R. and F.R.J., unpublished results), suggesting a model wherein LARK regulates different output pathways by interacting with distinct RNA targets.
However, manipulation of 5α-reductase activity with the inhibitor dutasteride failed to modulate disease in SBMA patients (Fernandez-Rhodes et al., 2011) or in a transgenic mouse model of SBMA (Maria Cho, Heather Montie, Mary Rosemiller, Yuhong Liu and D.E.M., unpublished results).
Furthermore, simultaneously blocking both VEGF and Dll4 can have more potent effects in a variety of tumour models than blockade of either factor alone (Ridgway et al, 2006; I Noguera-Troise et al, unpublished results), including this sarcoma model.
We are currently testing this hypothesis, and preliminary data have shown that deletion of the sap gene reduces the capacity of GBS to colonize the vagina in a mouse model of infection (Pezzicoli et al., unpublished results).
