We also noted that a significant number of lung transplant patients with pulmonary aspergillosis also receive mycophenolate mofetil; however, our studies to date indicate that its addition to the immunosuppressive drug regimen does not increase susceptibility to IFIs in this murine model (unpublished observations).
Polyclonal iTregs induced by stimulating T cells with anti-CD3/CD28-coated beads with IL-2 and TGFβ have also been recently found to have protective effects in this model and other mouse models of autoimmune disease [ 28]; in a collaboration with Antonio La Cava and Bevra Hahn at UCLA, we have found these polyclonal iTregs also have protective effects in the BWF1 model (unpublished observations).
Our previous report demonstrated that 63-kDa antigen entrapped in cationic liposomes induced reduction in parasite burden in BALB/c mice [22], and liposomal 34-kDa antigen was found to be ineffective to reduce parasite level in the same murine model (unpublished observation).
Interestingly, curcumin delivery was able to restore the levels of HSPs in these transgenic models (unpublished observations).
Although HER-2-specific antibodies do not seem to play a protective role in this particular mouse tumor model, they can be important in other models (our own unpublished observations) and a role for antibody-mediated rejection of HER-2-positive tumors has been well established by the therapeutic activity of trastuzumab.
The NOD gene region on chromosome 2, containing complement factor 5, and on the distal region of chromosome 1, containing FcγRs, influenced both antibody-induced arthritis models [ 114] (unpublished observations).
In contrast, these changes were observed only at ten weeks in the low-dose MIA model (Mohan G et al: unpublished observations).
These data are consistent with the idea that the loxP sites adjacent to the Snap23 exon 2 splice donor/acceptor sites interfered with Snap23 expression, a situation observed also in other mouse models ((15) and L.T., unpublished observations).
Lastly, decision-analytic models are constructed based on the available data and, in this case, certain model assumptions were based on unpublished observations.
We have shown that ERK1/2 promotes MLC2 phosphorylation through myosin light-chain kinase in mammary epithelial acini; however, a pharmacological inhibitor of calpain has had no effect on cell motility in our model (GW Pearson, unpublished observation).
A deterministic model was used, based on earlier models [4,11] (SF Awad and LJ Abu-Raddad, unpublished observations), to describe HIV transmission in Tanzania.
