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Intestinal metamorphosis is an excellent model to study the development of adult organ-specific stem cells.
The vertebrate retina is an excellent model to study the development of the nervous system including the cell differentiation process.
The chicken provides a novel and tractable model to study the development of the mononuclear phagocyte system and CSF1R signaling.
The zebrafish (Danio rerio) is a powerful genetic and developmental model to study the development of vertebrate circulatory system, especially hematopoiesis.
PCTS have been widely used as ex vivo model to study the development of liver and intestinal fibrosis (Westra et al., 2013).
Intestinal remodeling during amphibian metamorphosis resembles the maturation of mammalian intestine around birth and thus has served as a model to study the development of adult organ-specific stem cells in vertebrates [ 2, 4, 5, 9, 37– 437.
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Kwon, H. et al. Development of an in vitro model to study the impact of BMP-2 on metastasis to bone.
Its brain turned out to be too complex to analyze, but the worm nonetheless served as a wonderful model to study development of the animal embryo.
There are several models available to study the mechanisms of development of liver cancer in vivo.
Brenner was the first to recognize that C. elegans is a perfect model organism to study the very basics of complexity in animal development and neuroscience.
Chang, C. & Sternberg, P. W. C. elegans vulval development as a model system to study the cancer biology of EGFR signaling.
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