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Thus, it is possible for our model to recapitulate the behavior of the ribosome flow model – in which ribosomes are inexhaustibly abundant and the translation dynamics of each mRNA can be treated independently – but to do so requires assuming an unrealistic number of cellular ribosomes.
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One promising approach to modeling heterogeneous cell responses is to run 'populations' of models, to recapitulate the behavior of populations of cells.
U937 cells were chosen to recapitulate the behavior of differentiated monocytes that infiltrate actively inflamed intestinal tissues.
We tested whether the model recapitulated the behavior of gene expression observed in Olig2, Pax6, or Pax6 Olig2 mutant embryos.
This sensor reconstitutes α-catenin-dependent functions in α-catenin-depleted cells and recapitulates the behavior of the endogenous protein.
Furthermore, both Nup188 as well as Nup192 can translocate across intact NPCs in vitro, again recapitulating the behavior of NTRs.
In summary, this is an interesting model that emphasizes how few parameters are needed to recapitulate the course-grain behavior of eukaryotic chromosomes.
Their model is able to recapitulate the relevant dynamics of the Pde1 and Pde2 single mutants but does not account for the behavior of the PDE double mutant.
The HMEC model system promises to recapitulate the earliest stages of carcinogenesis in vitro.
However, these experimental models are unable to recapitulate the complex conditions of acute I/R injury.
They used a novel knock-in mouse model of CUL3WT/Δ403 459 to recapitulate the human PHA2E phenotype.
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