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We have generated a new mouse model to inactivate the Wwox tumor suppressor gene conditionally.
Dictyostelium provides a convenient model to inactivate specific genes and assess their role in intracellular killing.
We used this model to inactivate the NODAL and SHH pathways, both major pathways implicated in human HPE, during forebrain development.
Results In this study, the authors used a conditional Wt1 -knockout mouse model to inactivate the gene during three different stages of kidney development, before and after the mesenchymal-to-epithelial transition (MET).
To further examine the correlation between PTEN and the dopaminergic system, we developed a mouse transgenic model to inactivate PTEN signaling specifically in DA neurons.
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In particular, taking into consideration new experimental evidence provided independently from more laboratories, we discuss a model of regulation of aES assembly/disassembly upon the grounds of findings we obtained from an animal model that we generated appositely to inactivate the small Ras-like GTPase Rap1 [ 27].
B. anthracis ∆Sterne spores on nylon were the most difficult to inactivate and to model.
Several recent efforts to inactivate lncRNA genes in mouse models have shed light on their functions.
It could be due to the different model systems used in these studies, or the different approaches used to inactivate or remove the myosin head domain.
These results are consistent with a model in which the only requirement of cdk4 in MCF-7 cell proliferation is to inactivate pRb family members [26], [27].
A second-order polynomial model developed to inactivate Salmonella was found to be significant (p < 0.0001) with a R2 = 0.95 and a no significant lack of fit (p > 0.1073).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com