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The in vitro approaches aim at determining loss of substance via metabolism, and use a model to extrapolate from in vitro to whole body transformation rates [19].
For each organism, our results identify the pathways and processes for which S. cerevisiae is predicted to be a good model to extrapolate from.
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Where needed data did not exist, they created models to extrapolate from well-studied regions to countries with low data availability.
The majority of these evaluations applied some form of modelling to extrapolate from the short term effects on intermediate outcomes such as quitting smoking, weight reduction and lowering cholesterol levels to the outcome of interest: long term health in terms of mortality and quality of life.
However, the further the model had to extrapolate from the training conditions, the stronger was the constant bias in the sensorimotor transformations (even if both types of error remain small, <1.2°).
A combination of molecular modeling and simulation helps us to extrapolate from the structure of prokaryotic membrane proteins to the structure and dynamics of their human homologues, which may also aid in experimental structure determination.
If rigorously performed, this final step defeats the purpose of using the model system as a tool to extrapolate from, because all organism would be rigorously characterized beforehand.
2 The authors use a Markov decision analytical model to discount future events, to extrapolate from the two year RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial, 4 and they compare various health states using a well accepted metric, quality adjusted life year (QALY).
Molecular modeling techniques can be used to extrapolate from these to the structures of the corresponding human homologues.
Because all of the possible combinations of environmental variables are not represented in the geographic regions that occurrence points were drawn from, models would necessarily be required to extrapolate from that training data to predict suitability across the entire environmental space.
Researchers have therefore tended to extrapolate from these few results by using various computer models.
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