In an alternative model, cohesin has to dissociate from DNA to allow the passage of the replication fork, but is held in close proximity of the fork to re-associate with DNA immediately after, thus ensuring pairing of the replicated chromatids (Lengronne et al, 2006).
We suspect that this feature of our model system has provided us with additional leverage to dissociate models that emphasize correlations vs selective decoding.
Predictions from our computer model involving SCA15/16 could be compared with novel experiments in an existing mouse model using GST-IC4 to dissociate PP1α from IP3R1 in Purkinje neurons in cerebellar slices from ataxic mice.
Interestingly, aggregates of an HTT exon1-Q94 protexpressedssed in the brains of a mouse model required 3 weeks to dissociate after HTT exon1 expression was turned off.
In the mouse model, cranial neural crest cells fail to dissociate and migrate when Zfhx1b is knocked out [58].
The participants first completed two simultaneous two-step reinforcement-learning tasks that previously have been used to dissociate the contributions of model-based and model-free learning to choice behavior (Daw et al., 2011; Otto, Gershman, Markman, & Daw, 2013; Otto, Raio, Chiang, Phelps, & Daw, 2013).
These two classes of models have proven to be difficult to dissociate.
This allows the authors to dissociate the spectrum prediction model from the application assumptions.
For simplicity, in our model, WIPI1/2 and PtdIns3P are not allowed to dissociate from a ternary complex of ATG9, WIPI1/2 and PtdIns3P.
Thus, four solute descriptors of this model are related to the stability, reactivity, or the tendency to dissociate the carboxylic group.
