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Exact(35)
To estimate the probability of response in the base case analysis, subjects from the nVNS + SoC group who were responders throughout the extension phase were assumed to maintain this response until the end of the model time horizon (1 year).
DALYs averted were calculated for each cycle and accumulated over the model time horizon.
The model time horizon was 3 years, and the cycle length was 3 months.
With increasing model time horizon, the cumulative difference in QALYs grew.
As expected, the Markov model time horizon plays a relevant role in determining the ICER amount.
Costs and utilities were not discounted given that the model time horizon was less than a year.
Similar(25)
Using different discount rates or model time horizons had little impact on the cost-utility estimates.
Sensitivity analyses using varying discount rates of 0% and 6%, or varying model time horizons between 1 and 30 years favoured the OLAI treatment strategy.
−[41], p.85 lists the geographical scope (European Union) as well as the models' time horizon (1990 2050).
Because the duration to which ranolazine will remain efficacious is unclear, we did not attempt to extend the model's time horizon out to longer than 1 year, and thus this model should be considered hypothesis generating.
Omnes and colleagues [ 46] reported a model which has the most characteristics similar to ours in terms of model structure, time horizon, perspective, population, comparator, and effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com