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MOv18IgE, which targets folate receptor α (FRα), is a novel system to model this hypothesis.
At this stage, an attempt is made to try to model this hypothesis.
Recalling that a wide range of factors have been adjusted for in the model, this hypothesis does not make much sense.
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Modeling this hypothesis via GeneGo, we found that both TNF and MTHFR are influenced by a genetic feedback cycle that incorporates environmental ethanol exposure into folate metabolism.
For simplicity, we assumed that the level of tetrahydrofolate is lower in the wild-type culture and modeled this hypothesis with a single parameter (k ser → gly, Table 1).
Our finding that effect estimates for exposures derived from the 24-month back extrapolated model were intermediate between associations with exposures based on the nonextrapolated model and the 12-month extrapolated model supports this hypothesis.
In addition to the logistic regression model approach, this hypothesis will also be tested using survival analysis-based Cox regression analyses to predict time to onset of first mania, recognizing that individuals will have variable follow-up times.
The habitat suitability model corroborates this hypothesis by showing low suitability in regions where Japanese knotweed and mugwort are minor or benign introductions (e.g., the southwest and Mid-Atlantic), and occur in isolation.
The implemented model supported this hypothesis.
Results classifying galactosamine-treated rats using the multitoxicity model support this hypothesis.
Our second model tests this hypothesis by prescribing spatial gradients in calcium sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com