Under this model of meiotic drive ("centromere drive"), centromere sequences have the potential to mutate in such a way that new alleles could bias their own segregation into an egg, and so centromeres evolve rapidly as a result of repeated selective sweeps as such alleles drive to fixation [ 1, 8].
Intra-articular IL1Ra delivery did not result in marked improvement for this model; this may be driven by rapid clearance of administered IL1Ra from the joint space.
However, in our model this association is driven by rapid evolutionary dynamics instead of resulting from individual-level decision rules.
Although the initial GEE analysis provided evidence of an association between A64T and AIRg in African Americans (unadjusted p < 0.001, general model; P = 0.038, additive model), this result was driven by the presence of two minor allele homozygotes with high AIRg values and was not supported by simulation-based empirical p-values (P = 0.116, general model; P = 0.110, additive model).
However, both the time course of oligodendrocyte remyelination, and the unimpaired recovery relative to control mice in the absence of oligodendrocyte remyelination question both the role of oligodendrocyte remyelination in this model to drive recovery and the viability of this model to test remyelinating therapies.
"The real key is whether advertisers will embrace this model and drive online advertising revenue toward Wi-Fi hot spots," said Berge Ayvazian, chief strategy officer with the Yankee Group, a technology research and consulting group.
We develop a novel large-scale kinematic model for animating the left ventricle (LV) wall and use this model to drive the fluid structure interaction (FSI) between the ensuing blood flow and a mechanical heart valve prosthesis implanted in the aortic position of an anatomic LV/aorta configuration.
If successful, this model could drive standards and practices for the rest of the world.
A fan slope increase occurs when sediments reach the model limit, and this drives entrenchment.
Since Hb is an activator at low concentrations in the quadratic model, this indirect effect can drive eve expression between the stripes.
