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Finally, it should be noted that ∏ Q (t) was not assumed to be constant in our model; this assumption was made in [ 10] and criticized in [ 35].
P values were calculated assuming a Gaussian distribution of iHS scores under the neutral model, this assumption was checked by plotting the values against a Gaussian distribution.
We model this assumption by simply assuming that, in the wild-type model, the amplitude h, which is proportionally related to the mechanical damage, is negligible with respect to its counterpart in mdx mice.
Because insufficient longitudinal data exist for use in our model, this assumption clearly has a level of uncertainty; however, limited evidence suggests that it may be a reasonable one.
According to our model, this assumption can significantly change the basic properties of virus dynamics, especially if the infection term is a saturating function of the number of target cells.
However, since no variation in the incidence of AEs during the following chemotherapy cycles is reported in the pivotal trial, 11 and given that chemotherapy cycles end during the first year of the Markov model, this assumption does not impact on the ICER, since cost and outcomes occurring during the first year considered in an economic evaluation of health care programs are not discounted.
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Due to the richness of the genetic models, this assumption may not be appropriate.
If the missing value happened because of treatment-related toxicity or side effects, which were not included as covariates in the models, this assumption may not be appropriate.
So, if the model satisfies this assumption, positive evidence of model fit is available.
Previous models postulated symmetric binding energies for each state of the coarse-grained protein corresponding to the symmetry of the dimeric protein; this model relaxes this assumption by assigning different energies for the different steps in the unbinding process.
Our model challenges this assumption, in agreement with the measured gametocyte densities [21] and the growing perception that mass administration of antimarial drugs should be an important component of malaria eradication strategies [31] [33].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com