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In the BLM model, they observed that treatment with rapamycin enhanced autophagy and protected from fibrosis.
In this model, they observed a profound reduction in expression of CXCL8 that attenuated tumor associated angiogenesis.
Using an adoptive-transfer mouse model, they observed that IgG1-BCR-expressing memory B cells showed a higher propensity to differentiate into plasma cells compared to IgM-BCR-expressing mature naïve B cells, consistent with the observation from earlier studies.
Using their model, they observed that their data showed that the metastatic initiation occurred at a tumor volume of the primary lesion that was only slightly smaller than that at the time of tumor diagnosis.
When Mori et al [ 51] injected SOD at the time of a preconditioning ischemia (focal ischemia model), they observed strong attenuation of the protection against the subsequent lethal ischemia.
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In addition, when they seeded keratinocytes onto the dermal models, they observed reversible sizes and morphological changes.
In two breast cancer xenograft models, they observed significant correlations between tumour uptake of the radiolabelled ligands and growth and proliferative status of the tumours (Fig. 2).
Aerosol infectivity studies of human volunteers have little information for dose-response modeling because they observed 100% of volunteers to become infected: Exposures were ≥ 16 TCID50 [ 47] and ≥ 17 TCID50 rhinovirus NIH 1734 [ 48].
In BAFF transgenic mice, considered a model for SLE, they observed SS-like disease characterised by severe sialadenitis, decreased saliva production and destruction of submandibular glands [ 35].
When they modeled this data, they observed signatures in sick babies that were different from the ones they observed in healthy ones.
He believes that in future, "economists will routinely incorporate as much 'behaviour' into their models as they observe in the real world.
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Justyna Jupowicz-Kozak
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