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Applying an additive genetic model the minor diabetes-associated G-allele of the TP53 rshowed22 showed nominal association with higher levels of fasting plasma glucose (P = 0.03) (Table 2).
In the dominant model, the minor variant T allele also significantly influenced the objective response in all patients (C/T+T/T vs. C/C: OR, 2.42; 95% CI, 1.88-3.10; P = 0.830 for heterogeneity, I2 = 0.0%).
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The model loci had a dominant model for the minor allele with MAF of 0.2.
Association testing for each transformed metal was performed in a linear regression framework under an additive model in the minor allele for each variant in turn, after adjusting for triglycerides, cholesterol, gender and two principle components from multidimensional scaling to account for population structure as covariates.
To allow zooming into the generalized model, we keep the same coordinates as in the generalized model for the minor metabolites and the ungeneralized metabolites and reactions, and place similar metabolites or reactions next to each other inside the space used by the corresponding generalized metabolites or reactions in the generalized model.
Dominant and recessive models were performed, modeling both the minor and major allele as the risk alleles.
Genetic associations were assessed using both an additive per allele model (as supported by the associations with long-chain fatty acids [19], [20]) and a recessive model for the minor allele (as reported by Caspi et al [23]).
The model uses the minor earthquakes to forecast the major events, and requires catalogue completeness at nearly two orders of magnitude below the target magnitude threshold.
To conclude, the main system dynamics are well captured by the model and the minor discrepancies are easily justified by the simplifying assumptions, often leading to optimistic predictions.
The pressure and molar flow rate distributions for the fuel and oxidant streams in the stack are determined with a flow network model incorporating the minor losses.
Extensions of the model for the minor anions of natural waters at the present time are difficult due to the lack of reliable activity coefficient data for Na, K, Mg and Ca salts over a wide range of temperatures.
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