In comparison, using the mechanistic PK model the metabolic rate constant derived for unbound HC (k metabolism,unbound) is unaffected by HSA concentration (P = 0.22), although it was still dependent on cell culture period (P = 0.0082).
In order to model the metabolic integration of C2 and C4 cycle in the context of leaf metabolism, we conducted Flux Balance Analysis (FBA) based on a genome-scale metabolic reconstruction of C4 metabolism, C4GEM (Dal'Molin et al., 2010).
Our aim is to construct a practical dynamic-simulation system that can model the metabolic and regulatory processes involved in the production of primary metabolites, such as amino acids.
In order to properly model the metabolic transition from aerobic to anaerobic conditions, the roles of global regulators such as ArcA/B and Fnr must be properly incorporated, where the effect of dissolved oxygen concentration on the activation of such TFs has been reported [167,168], and this may be taken into account for the simulation under microaerobic conditions.
According to the predictions of the WBE model, the metabolic rate of plants, B; rate of biomass production, G; photosynthetic biomass, Mp (i.e. the total leaf biomass, ML); covary and all should be proportional to the 3/4 power of total plant mass, M, i.e. B∝G≈MP orML ∝M3/4[3], [6] [8].
PLS-DA was used to model the metabolic profiling data among CK, SK, and NC.
It highlighted the key biological processes that influence arsenic metabolism by explicitly modelling the metabolic network of GSH-adducts formation.
It highlights the key biological processes that influence arsenic metabolism by explicitly modelling the metabolic network of GSH-adducts formation [ 27].
The NETWORK component models the metabolic network using the constraint-based modeling framework [ 3].
The NETWORK component, the actual network of reactions, models the metabolic conversion capabilities of the organism.
Modeling the metabolic network consists in choosing which biological objects are associated to nodes and edges.
