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They used millions of closed-packed hexagonal lobules (radius 0.6 mm and length 1.5 mm) to model the liver parenchyma, and the microspheres were uniformly distributed in the portal tracts in the corners of the lobules.
The high levels of CXCL12 found in the primary tumour site (adrenal gland) and in a major site of metastasis in our model (the liver) support the notion that it may confer survival and proliferative advantages to the NB cells and is consistent with a critical role of tumour microenvironment in primary and secondary tumour growth.
In this model, the liver iron deposition derived from the augmented erythrocyte phagocytosis induced insulin resistance, hepatic lipid accumulation, Kupffer cell activation, mild fibrosis, and increased oxidative stress.
In this model, the liver showed higher levels of total bilirubin, aspartate aminotransferase, alanine transaminase, and hyaluronic acid after 8 weeks of treatment.
To assess the effects of hepatic and renal function, we also repeated these analyses, adding to the model the liver enzyme γ-glutamyl transferase, and glomerular filtration rate, a measure of renal function.
In our model, the liver showed a high fungal burden and a consistent decrease of the burden over time, and a low inter-individual variation at early and mid-time-points, making it the most robust target organ for barcode-based in vivo detection of C. glabrata pools.
Similar(54)
The second compartment models the liver, which was included for its prominent role in the upregulation of acute-phase proteins associated with Crohn's disease, such as CRP.
This is achieved by modeling the liver as a permeability-limited tissue, incorporating active uptake and passive diffusion of unbound drug at the sinusoidal membrane and biliary efflux of unbound drug at the canalicular membrane.
Ricken et al. (2010) developed a poroelastic model of the liver tissue and combined this with a model of the development of sinusoidal orientation to model remodeling of the liver tissue after injury.
"We scan the patient, derive a 3D model of the liver with the vessels, and in that model we see the tumours so we can tell the surgeon where to cut.
If datacells with DS86 dose below 5 mSv are excluded from the 0 – 20 mSv dose range, the two-phase model is no longer a significant improvement on the linear model for the liver.
Related(20)
model the kidney
system the liver
example the liver
sample the liver
model the cancer
model the lung
models the liver
model the probability
model the head
model the impact
model the weather
model the effect
model the affinity
model the behavior
model the average
model the aspiring
model the climate
model the city
model the Coupé
model the coach
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