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Under the multiple glacial refuge model, the extant population structure of haplotypes results from isolation and divergence within four hypothesized glacial refugia.
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However, in spite of the available data, no evolutionary model explaining the extant scenario has been proposed.
The modeling of the extant data constrains these variables, and the potential impact of the recent HESS detection on such parameters is addressed.
Data obtained supports an evolutionary model suggesting that the extant hisA/hisF structure could have arisen by two sequential gene elongation events, each of which doubled the length of the ancestral gene and the number of -modules in the product.
A possible evolutionary model leading to the extant metabolic scenarios was also depicted.
In contrast, the 'evolutionary cradles' model predicts that the extant diversity is the result of recent and rapid accumulation of species via high speciation rates [ 4, 12].
Our model predicts that the extant diversity of the orchid perianth results from changes in expression of some of these four DEF-like genes, or from changes in the downstream targets of the proteins that they encode [ 42].
Furthermore, a climate niche modelling based on the extant distribution of mitochondrial lineages predicted a very congruent northern limit of ' italica', while euphorbiae could potentially be present throughout Italy [ 31].
We evaluated the predictions of the model with respect to the extant literature, focusing on studies in which versions of hypertexts were compared.
The observed closer sequence relationship of collagen XXIII and XXV proteins are explained most parsimoniously by the model that these represent the extant forms arising from one pair of duplicated genes produced in the second round of genome duplication (Fig. 9).
Furthermore, the same group of investigators who developed original models has mainly conducted the extant validation studies.
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