Despite these similarities with adult HCM models, the embryonic zebrafish heart did not display cardiomyocyte hypertrophy in response to this sarcomeric mutation, but rather developed significant cardiomyocyte hyperplasia.
We use a model of the embryonic cell cycle to illustrate the approaches that can be used to characterize the domain of parameter space corresponding to limit cycle oscillations, a regime that coordinates periodic entry into and exit from mitosis.
We propose a computational model of the embryonic stem cell network, in which a core set of transcription factors (TFs) interact with each other and are induced by external factors.
In the work of Pomerening et al. [ 18], a numerical model of the embryonic cell-cycle network was developed, in which the CDK1 activity was increased by dual positive feedback, while the CDK1 activity was reduced by a single negative feedback to explain the possible underlying bistability of the network.
To first establish a Drosophila model for the embryonic development defects associated with the PBDs, we performed a systematic double stranded (ds)RNA knockdown screen in embryonically derived Schneider 2 (S2) cells to confirm homologous roles of the 14 Drosophila genes homologous to known PEX genes in other organisms (Fig. 1) (Chen et al., 2010).
These two models describing the embryonic origin of hematopoietic cells have been regarded as mutually exclusive for many years.
In the last years, conditional animal models overcoming the embryonic lethality of the DG knock-out in mouse have been generated and helped clarifying the crucial role of DG in skeletal muscle, while an increasing number of studies on knock-in mice are aimed at understanding the contribution of single amino acids to the stability of DG and to the possible development of muscular dystrophy.
To address these issues we first use micro-aspiration to test whether a small-deformation model that treats the embryonic tissue as a homogenous, linearly viscoelastic material is adequate to describe the mechanical properties of the dorsal marginal zone as it undergoes large deformations.
In our model, condensation of the embryonic rudiment plays a central role in remodeling the single-layered blastoderm into the multi-layered enveloped germband.
Our findings support a model in which the embryonic OHC region maintains a compartment of Sema3F protein expression, which activates Nrp2 receptors expressed on SGNs leading to retraction of processes.
