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Using a mouse model, the efficacy of these arteether lipid formulations against Plasmodium berghei was evaluated.
Strikingly, in the 4T1Ch9 model, the efficacy of either α-4-1BB/MEKi or α-OX-40/MEKi was significantly greater (two-way ANOVA; P < 0.0001) than the combination of α-PD-1 and MEKi (Fig. 7a, b).
Therefore, in a swine model, the efficacy of CO2 removal at a dialysis flow rate using regional trisodium citrate anticoagulant and also systemic anticoagulant was determined utilizing a modified renal dialysis unit.
Here we have determined in the DIO mouse model the efficacy of a related small molecule compound, Genz-112638, which is currently being evaluated clinically for the treatment of Gaucher disease, a lysosomal storage disorder.
In the model, the efficacy differences were conveyed through transition probabilities.
For example, a study trying to model the efficacy of RNAi experiments is given in [ 28].
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After studies in preclinical mouse models, the efficacy and safety of tumor-specific vaccination strategies is currently being evaluated in cancer patients.
We modeled the efficacy of the ICD as a reduction in the relative risk of death on the basis of the hazard ratios reported in the individual clinical trials.
On the basis of these results, we chose the underlying distribution for modeling the efficacy of combination vaccines as a normal distribution on the log immune response such that the fold range is 65 on the untransformed responses.
Hence, it will be interesting to investigate and compare in further studies with animal models the efficacy of inactivated and live-attenuated vaccines to provide protection against infection with the pandemic (H1N1) 2009 virus.
Modeling the efficacy of various drugs in combination, however, should consider nonlinear dependencies.
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