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To model the cellular and molecular context of ATRX-mutant gliomagenesis, we inactivated Atrx in Tp53-intact and deficient murine neuroepithelial progenitors (mNPCs).
To this end, Dr. Glade Bender and team will leverage novel cancer systems biology approaches, developed by Dr. Califano and the Califano lab at CUIMC, that model the cellular logic of cancer cells, using supercomputers to identify optimal treatment options for each patient.
These findings will help more accurately model the cellular mechanical environment in mesenchymal tissues, which could assist in describing injury thresholds and disease progression or even determining the influence of mechanical loading for tissue engineering efforts.
In the analytical model, the cellular core is represented using a rigid, perfectly-plastic, locking idealization, as in previous studies, and the front and back faces are modeled as rigid, with pressure loading applied to the front face and the back-face unrestrained.
Future studies should measure and model the cellular structure precisely and also reproduce the mechanical fields to correlate with intracellular responses such as stress fiber formation.
We used a new approach to model the cellular interactions between macrophage activation types in the post-MI setting.
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Biological dosimeters are usually simple organisms, or components of them, modeling the cellular DNA.
The former models the cellular structure in detail whilst, the latter models the fluid saturated porous structure using volume averaging techniques.
FoldEco models the cellular proteostasis network of the E. coli cytoplasm, including protein synthesis, degradation, aggregation, chaperone systems, and the folding characteristics of protein clients.
The cell reprogramming technology enables a reverse engineering approach for modeling the cellular degenerative phenotypes of a wide range of human disorders.
In view of these considerations, one could question the validity of the in vitro hiPSC phenotype for modelling the cellular pathophysiology caused by sarcomeric mutations.
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