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Depending on the model, the cells are embedded in the outer region of the ECM ring or the inner region.
In an early version of the model the cells always died when the value of Nmax death was reached.
In our model the cells were responding to locally variable microenvironment therefore they were not functionally synchronized.
In this model, the cells express high level of multi-drug resistant (MDR1) protein, which pumps out the anticancer drugs such as doxorubicin (Dox).
No expression was seen for Atoh1 or Cntn1, suggesting, in this model, the cells generating tumours did not resemble granule cell progenitors.
In the context of the veto model, the cells behaved as if they had a smaller number of flagella than what they actually had.
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In the actin-dependent migration model, the cell is pushed forward by the biochemical equivalent of a boat engine.
Based on the RC model, the cell capacitance can be extracted.
Therefore, we will model the cell threshold voltage distribution f(x) by the following GMM.
For the characterization of the BBB model, the cell morphology of monolayer was initially observed by phase contrast optical microscopy.
Using the series RC model, the cell capacitance can be calculated and is plotted in Fig. 4c.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com