Sentence examples for model the accumulation from inspiring English sources

Acquisition of one mutation will not necessarily reduce the clinical efficacy of a regimen; thus we did not model the accumulation of mutations, we modeled the virological failure rate due to acquired resistance.

Although the exact nature of Gr-1dim/Ly-6Gdim cells remains to be established, there is no doubt that in our model, the accumulation of these cells in the lungs was the major cellular characteristic of TB progression.

Indeed, in this model the accumulation of aberrant mitochondria into inclusions seems to be independent of α-syn [ 120].

Moreover, as long as we cannot accurately model the accumulation of the neurotoxic species, we cannot be certain that therapeutic intervention will produce the desired outcome.

To experimentally verify the regulatory role of the 6 candidate TFs in the proposed TF-target model, the accumulation of starch metabolic gene transcripts was determined using homozygous knockout lines.

In different models of frailty, like the Functional Domains model (the accumulation of deficits), the Burden model (the index of health burden) and the Biologic Syndrome model (frailty as a biological syndrome) multidimensional screening instruments are considered to be most appropriate in screening frailty [ 44].

The second study, by Evans & Steinsaltz (2006), also models the accumulation of damage that affects survival probability, and is thus closer to the scenario investigated here.

We modeled the accumulation of susceptible individuals over the time on the basis of vaccination coverage, vaccine efficacy and birth rate.

For example, the accumulation of α-synuclein oligomers was found in PD patients [ 17], while, in cell line and mouse HD models, the accumulation of intracellular polyglutamine oligomers was suggested to be directly related to HD phenotypes [ 18].

The added requirement of making predictions on currently annotated proteins makes CAFA2 a more realistic representation of the function prediction problem, as it better models the accumulation of annotations over time.

To help develop testable predictions, Nunney (1999a) modelled the accumulation of somatic mutations in the development of cancer during two stages of development, growth and stem cell maintenance, and here, we focus on the stage of postgrowth maintenance, because he noted that a simple approximation allows the growth phase to be incorporated into that model.