A novel animal model that recapitulates human CSCD was generated.
Our team has developed [21] and optimized [22] an orthotopic dog prostate carcinoma (DPC-1) model that recapitulates the advanced form of PCa in dogs.
It is becoming apparent that a synergistic team composed of three drivers (one 'first driver' and two 'synergistic drivers') may be required to generate an animal model that recapitulates aggressive osteosarcoma with a short latency.
In the current study, we evaluated nAChR subtypes in brain regions of rats subjected to olfactory bulbectomy (OBX), a standard animal model that recapitulates many of the behavioral and neurochemical alterations thought to underlie human depression.
The objective of this study was to establish a large animal model that recapitulates the spectrum of intervertebral disc degeneration that occurs in humans and which is suitable for pre-clinical evaluation of a wide range of experimental therapeutics.
One of the challenges in ovarian cancer research is the absence of an experimental animal model that recapitulates the human disease that can be experimentally manipulated [1], [3].
We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC.
A liver model that recapitulates key features of hepatic sinusoids is a potentially powerful medium for obtaining comprehensive knowledge on metabolism, detoxification and signaling pathways.
The CBA/J x DBA/2 model, that recapitulates the key preeclamptic symptoms, helped us identify mediators of PE and identify possible therapies.
In this study, we used the ferret model that recapitulates the efficient transmission of seasonal influenza viruses and the poor transmission of avian influenza viruses in humans [13], [14], [15], [16].
Using this animal model that recapitulates many of the features of preeclampsia in women, we found that pravastatin restores angiogenic balance, ameliorates glomerular injury, diminishes hypersensitivity to angiotensin II and protects pregnancies.
