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A key prediction of the model, that increased striatal acetylcholine levels will increase β power, was verified in rodent experiments as part of the same study.
However, in contrast to this general scheme of reactivation of the foetal gene programme with SERCA downregulation, we have previously demonstrated in an in vitro model that increased load immediately increases SERCA expression.
Ghedini et al (2010) has recently shown in an animal model, that increased circulating levels of recombinant Her2/neu ECD (rECD) may indeed decrease and delay Her2-positive tumour growth in a Her2/neu genetically engineered ovarian cancer model.
These data support the model that increased Bim expression in CXCL12-producing cells plays key roles in decreased metastatic potential relative to primary tumor growth of those colonic carcinoma cells.
Our data thus support the model that increased uPA expression at the cell surface substantially increases pln generation, and therefore invasive potential, via a positive feedback mechanism.
Hence, taken together the data with the Wnt and CDK inhibitors fulfil the predictions of the model that increased levels of NICD will be associated with an increase to the periodicity of clock gene oscillations.
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There are extensions to this model that increases its power.
It has been shown in other human cancer models that increased efficacy of cisplatin may be achieved by NF-κB inhibitors in cancer cells [ 17, 18].
We make modeling tools and code available (e.g., Bayesian geostastical models) that increase DSM capabilities and support existing efforts toward the production of improved digital soil products with limited data.
While the managers adjust pricing, O'Leary's computer programmers are working to develop genetic algorithms;models that increase the computer's knowledge with experience.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com