Because neuronal nicotinic receptors have been implicated in mood regulation as well as in reinforcing effects of alcohol, it was of interest to determine whether inherent changes in these receptors may be manifested in an animal model that expresses both depressive-like characteristics and high alcohol intake.
This model is further supported by the heightened pathology and increased mortality reported in a CM double heterozygous mouse model that expresses both strong (R403Q Myosin) and moderate activator (G203S cTnI) alleles [28].
The MDSFR method utilizes a semi-empirical model that expresses the collected single fiber reflectance intensity as a function of fiber diameter (d fiber), μ′ s, and γ.
The final model, reported by Li and co-workers, was a conditional knock-in model that expresses the human JAK2V617F (Li et al., 2010).
Among the most interesting ones is a rat tg model that expresses Swe/Ind mutant hAPP751 (K670N/M671L, V717F) alone or with mutant PS1 (M146L) under the control of the PDGF-β promoter (Echeverria et al. 2004a, b).
Recently, a transgenic zebrafish model that expresses AML1-ETO oncogenes has been reported as an excellent animal model for uncovering new therapeutic targets involved in oncogene-regulated hematopoietic differentiation [ 71].
In light of our recent findings and to investigate the potential interaction between Wnt and ILK proteins during mammary tumor formation and progression, we established a transgenic mouse model that expresses both Wnt and ILK in mammary epithelial cells.
In order to explore the effect of the mutants in this context, they were investigated using a COS-7 cell model that expresses the common severe Z mutant (E342K) of α1-antitrypsin.
To study the molecular processes leading to atrophy in DM1 adult muscle tissue, we generated a fly model that expresses toxic CUG transcripts under the control of the heat-shock (HS -inducible promoter HS -inducible
To explore whether chronic cerebral hypoperfusion is associated with the relationship between CMIs and CAA, we used a transgenic mouse CAA model that expresses human vasculotropic Swedish/Dutch/Iowa mutant amyloid precursor protein (APP) (Tg-SwDI mice) [ 11] and subjected them to bilateral common carotid artery stenosis (BCAS) to mimic chronic cerebral hypoperfusion [ 37].
To help identify new components of CTG toxicity, we previously used a fly model that expresses 480 interrupted CTG repeats in an enhancer-suppressor genetic screen of 695 lethal P-element insertion mutant lines, covering ∼5% of the Drosophila genome (Garcia-Lopez et al., 2008).
