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Most CAD software are designed for creation of endless geometric diversities; however, splint design is a regular task involving generation of a model that exhibits specific features.
In cancer research, the multi-cellular tumor spheroid (MCTS) model is an established 3D cancer model that exhibits microenvironmental heterogeneity close to that of tumors in vivo.
Because IKBKAP gene knock out causes embryonic lethality [19], an animal model that exhibits the major phenotypic characteristics observed in FD humans has not yet been established.
Therefore, MJFF has employed ZFN technology to knock out DJ-1 in the rat and generate an animal model that exhibits gait and locomotor deficits (our unpublished data, in preparation).
In a 3xTg-AD mouse model, that exhibits both A β and tau pathologies [ 111], DHA supplementation caused a significant reduction in soluble and intraneuronal A β levels as well as tau phosphorylation [ 112].
Therefore, an animal model that exhibits decreased PPI and P50 suppression and poor performance on tests of vigilance and working memory will engender more confidence in its validity for schizophrenia than an animal model that only exhibits one of these features.
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Experimentally, we used a xenograft of human inflammatory breast cancer (MARY-X), a model that exhibited florid tumor emboli, to generate tumoral spheroids in vitro.
We conclude by presenting a relatively simple "wedge-model" that exhibits key emergent properties of convergent extension such as the coupling between tissue stiffness, cell intercalation forces, and tissue elongation forces.
There are currently two major categories of animal models that exhibit manic-like behaviors.
Phase oscillators are a common starting point for the reduced description of many single neuron models that exhibit a strongly attracting limit cycle.
This facilitates derivation of new forms of thermodynamical models that exhibit both global continuous behavior and the phenomenon of abrupt stiffness change within a single package.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com