While the LM-OVA model showed a clear correlation between the timing of early CD8+ T cell activation and upregulation of caspase-3 activity, we were interested in determining the expression of caspase-3 during another infection model that differed in the degree and timing of antigen-presentation.
First, we developed a congenic mouse model that differed genotypically from the control mice only in two non-MHC loci, namely Nss1 and Idd5.
The licenses ultimately ended up in the possession of Myriad, but for a brief period both firms had intellectual property and offered commercial BRCA testing, giving us the opportunity to retrospectively analyze the divergent corporate practice models, clarifying the elements of Myriad's business model that differed from OncorMed's and that tarnished Myriad's public image.
Thus, using two different infection models that differ in the relative expression of antigen versus inflammation, we have shown that TCR signaling, and not inflammation, is the key mechanism that drives the induction of caspase-3.
To better understand the potential implications of these different scenarios, we constructed mathematical models that differ primarily in the nature of the interactions between DNA binding and non-binding components (Fig. S1– S1 ).
We expect the observed relationships between the results from the various techniques to be applicable to some other models, but different relationships might be expected in models that differ greatly from that used here.
Each geological model is split into two identical architectural models that differ in their sedimentary fill.
Currently, there are several UPN models that differ in the architectures and services they offer to users.
Open image in new window Fig. 1 Results of pushover analysis, for models that differ only in component reinforcement quantity.
This "assumption" is ultimately dropped in our empirical analysis when we estimate models that differ across occupations.
