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The prediction of our theoretical model that alternative splicing is favored by a strong tissue specificity in splicing variant expression fits well with the observation that PS genes are expressed in more tissues than MS genes (Figure 2B).
Our findings are contradictory to previous reports in model animal species in which duplicated genes tend to have fewer alternative spliced isoforms thereby supporting the 'function-sharing model' that alternative splicing and gene duplication are two mechanisms that are complementary with respect to proteomic function diversity [ 37, 38].
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The accelerated failure time model is a parametric model that provides an alternative to proportional hazards models commonly used in time-to-event analyses.
The main idea of modelMaGe is simple: model alternatives are generated from a master model that includes all alternatives of interest.
In addition, gene models that had alternative model predictions which were longer were explored using InterProscan5 and manually corrected where applicable.
Using this set of models, we obtained the log likelihood estimates (L) of a tree topology under models that impose alternative assumptions in terms of rate variation (ω = dN/ dS) over different codon sites [ 29, 30].
Indeed, a common problem in modeling biological networks is that alternative, structurally different models can fit experimental data equally well [ 8].
The question is whether there is any alternative model that makes sense for his proposed union.
"But now that it has failed, there is really no alternative model that is attractive to governments unable or unwilling to forgo drilling solely on ecological grounds".
An alternative model that has been extensively discussed is some sort of micropayment system for news sites.
The question is whether there is an alternative model that better aligns founders, investors, and employees for growth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com