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These are generally built in a piecewise manner based on model systems representing interactions found in proteins and are then extended to full protein systems.
Using shRNA-mediated technology, Dab2 was stably downregulated in two cell model systems representing nontumourigenic human mammary epithelial cells.
However, it is widely accepted that for understanding of the plant morphological evolution new model systems representing different lineages of the angiosperms should be selected [ 12, 13].
Developing better model systems representing both human stromal and epithelial cells will enable these emerging therapies to be tested more critically.
Once a model is established, faster and more efficient methods are required to validate computational results in cellular and animal model systems, representing a huge challenge in the field of integrative omics science [ 28].
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Animal model systems represent an important adjunct and surrogate to studies of OA in humans.
Although the current model systems represent well the highly successful and derived lineages in which they occur, they do not represent the overall diversity of angiosperms.
Nevertheless, one should not forget to what extent the model systems represent artificial situations, which can only partially portray the disease of a patient, and which are frequently based on powerful pharmacological or toxicological means.
The yeast Saccharomyces cerevisiae is now recognized as a model system representing a simple eukaryote whose genome can be easily manipulated.
We sought to apply this technology to a cellular model system representing a highly metabolically active state.
However, we created a fairly unique CML model system, representing CML in its chronic phase with imatinib sensitivity (S cells) and CML with various determinants of imatinib resistance.
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